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[2017-04-24] The Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: An open-label trial.(Report) from: Phytomedicine: Journal of Phytotherapy & Phytopharmacology

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Yokukansan is a medicine inspired by the original Chinese formulation Yi-Gan San. Both of them use the same characters; they are traditional Asian herbal medicines. Yokukansan (YKS) contains an exactly measured[3] mixture of dried herbs, 4 g of Atractylodis lanceae rhizoma, 4 g of Poria, 3 g of Cnidii rhizoma, 3 g of Angelicae radix, 2 g of Bupleuri radix, 1.5 g of Glycyrrhizae radix, and 3 g of Uncariae uncis cum ramulus. These herbs are registered in the Pharmacopoeia of Japan ver. 15. Patients take 2.5 g of YKS powder (1.08 g extract) three times a day. YKS has been approved by the Ministry of Health, Labour and Welfare (Japan) as prescriptions covered under the National Health Insurance plan. Note of caution: the Chinese TCM corresponding formula Yi-Gan San, is not identical to YKS, it is merely inspired by it, despite using the same Kanji (this is true of all Kampo). There are many factors which make them different and therefore one may not substitute the corresponding TCM formulation and expect the same results -- from growing methods to processing to formulation to regulations.

Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: An open-label trial.(Report): An article from: Phytomedicine: ... Journal of Phytotherapy & Phytopharmacology


Previous clinical trials suggest that the traditional Japanese medicine yokukansan has beneficial effects on the behavioral and psychological symptoms of dementia (BPSD). The present study was conducted to elucidate the efficacy of yokukansan on BPSD in patients with vascular dementia. Thirteen Japanese patients (9 men and 4 women) who were diagnosed as having vascular dementia (VaD) according to the diagnostic criteria of NINDS-AIREN were subjected to the open-label clinical trial in which yokukansan (7.5g/day) has been given for 4 weeks. Their mean age was 71.2±6.5 years. The BPSD was evaluated using the Neuropsychiatric Inventory (NPI), cognitive function was evaluated by the Mini-Mental State Examination (MMSE), the activities of daily living was evaluated by Barthel index (BI) and Disability Assessment for Dementia (DAD), and the extrapyramidal signs were evaluated by United Parkinson's Disease Rating Scale (UPDRS). The mean NPI was 33.0±17.3 and 23.6±13.9 for the baseline and after treatment, respectively.

It was significantly improved after treatment (p<0.05). In the NPI-subcategories, there was a significant improvement in agitation and disinhibition after the treatment. There was no significant change in MMSE, BI, DAD or UPDRS before and after the treatment. There was no adverse effect during the treatment period. The present results suggest that yokukansan is beneficial for the treatment of BPSD in VaD patients. Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: An open-label trial.(Report): An article from: Phytomedicine: Journal of Phytotherapy & Phytopharmacology



Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: An open-label trial.(Report): An article from: Phytomedicine: ... Journal of Phytotherapy & Phytopharmacology


This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Urban & Fischer Verlag on April 15, 2012. The length of the article is 4539 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. The article title is Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: An open-label trial, written by the author Ken Nagata. It is published in Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Magazine/Journal) on April 15, 2012 by the publisher Urban & Fischer Verlag.

Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: An open-label trial.(Report): An article from: Phytomedicine: ... Journal of Phytotherapy & Phytopharmacology
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